Olejar Books

The G-protein coupled receptors (GPCRs) and associated peripheral G-proteins underpin a multitude of physiological processes. The GPCRs represent one of the largest super families in the human genome and are a significant target for pharmaceuticals as well as bioactive and drug discovery programs. It is estimated that greater than 50% of all drugs including those in development currently target GPCRs. Indeed, many of the GPCRs identified have known ligands, however, approximately 20% of GPCRs are described as orphan GPCRs (apparent GPCRs that have a similar structure to other identified GPCRs but whose endogenous, natural ligand is not known). The general aim of this book is to provide researchers with a range of protocols that may be useful in their GPCR drug discovery programs. It is also the basis or a starting point for the development of future assays in this field. Therefore, the range of topics covered and the appropriate methodological approaches in GPCR drug discovery are reflected in this book.